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KMID : 1137020240350010006
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Journal of Gynecologic Oncology
2024 Volume.35 No. 1 p.6 ~ p.6
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Feasibility, accuracy and acceptability of self-sampled human papillomavirus testing using careHPV in Cambodia: a cross-sectional study
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Sovanara Hang
Rei Haruyama
Kyna Uy
Noriko Fujita
Tadashi Kimura
Kanal Koum
Kei Kawana
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Abstract
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Objective: Self-sampled human papillomavirus (HPV) testing is a potential option for cervical cancer screening, but research is scarce in Cambodia. We evaluated the feasibility, accuracy, and acceptability of self-sampled HPV testing using careHPV.
Methods: A cross-sectional study including women aged 20?49 years attending 2 national hospitals in the capital city was conducted. Women underwent both self-sampling and clinician-sampling of specimens, and were then asked to complete an acceptability questionnaire. The paired samples were analyzed for high-risk HPV by careHPV and genotyped by polymerase chain reaction (PCR).
Results: A total of 375 women were eligible for inclusion. Based on PCR, 78.9% were negative for HPV in both self and clinician-samples, 9.9% had a complete HPV type match, and 6.1% had all HPV types in clinician-samples also detected in self-samples. In 5.1%, one or more HPV types identified in the clinician-samples were missed in self-samples. When using careHPV, the overall agreement between the 2 sampling methods was 95.7% (95% confidence interval [CI]=95.8?95.6) with good concordance (κ=0.66, 95% CI=0.56?0.76). Nearly 90% of the women preferred clinician-sampling over self-sampling, citing greater comfort, ease, and speed.
Conclusion: Self-sampled HPV testing using careHPV could be an option for cervical cancer screening in Cambodia; however, it requires periodic quality control of handling procedures. In addition, women’s health education regarding the accuracy of self-sampled HPV testing and the importance of follow-up in cases of positive results is needed.
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KEYWORD
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Cambodia, Uterine Cervical Neoplasms, Early Detection of Cancer Papillomavirus Infections
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